国产熟妇婬乱A片免费看牛牛,苍井空亚洲精品AA片在线播放,国产超碰人人模人人爽人人添,丝袜A片午夜www丝袜,17c在线精品无码秘 入口

{{ date }}     {{ week }}    {{ time }}

Adiponectin

Date:2020-03-18   Views:2889

     The conditions of obesity and overweight pose a major risk for a number of comorbidities, including clinical syndromes resulting from atherosclerotic disease.
Adiponectin is known as an important adipokine and is involved in various biological processes in the human body. The change in the profile of serum adipokines in obese subjects, such as levels of adiponectin and pro-inflammatory cytokines, are proposed as a contributing factor to the development of cardiometabolic alterations[1].
    Adiponectin acts as a protective factor for cardiovascular disease, increases insulin sensitivity and has a beneficial effect on postprandial glucose and lipid metabolism[2].  Its levels are lower in obese people compared to the non-obese, as well as in individuals identified as insulin resistant; patients with T2DM, high blood pressure and particularly patients with coronary heart disease[3].
     Adiponectin is a 30 kDa protein with a C-terminal globular domain and a collagen-like N-terminal domain[4].
     Adiponectin, a product of the APM1 gene, is a protein composed of 244 amino acids, also known as GBP-28 (galatin binding protein-28), ADOPOQ and ACRP30. This protein is largely secreted by adipocytes, although it can also be secreted by cardiomyocytes, hepatocytes and placenta at lower concentrations[5].

                                                        

Domains and structure of adiponectin


   Full-length adiponectin is composed of 244 amino acids, including a collagen-like fibrous domain at the N-terminus and a C1q-like globular domain at the C-terminus. In circulation, adiponectin forms low-molecular weight (LMW) homotrimers and hexamers, and high-molecular weight (HMW) multimers of 12–18 monomers. A smaller form of adiponectin that consists of globular domain also exists in plasma in negligible amounts. Each adiponectin subunit in the basic trimeric building block represented in a different color[6].
    Adiponectin is mainly produced from white adipose tissue and specifically in mature adipocytes.The concentra-tion of circulating adiponectin in plasma is very high (2 to 30 μg/mL)[7,8].
    Adiponectin is a key mediator of systemic insulin sensitivity and glucose homeostasis. These effects are achieved through a diverse range of important targets, including liver, pancreas, cardiac myocytes and immune system, and the adipose tissue itself. The main metabolic effects of adipo-nectin are suppression of hepatic glucose production and modulation of suppressing inflammatory responses in other cell types, including macrophages[1].

News

NewsEvents

Contact Us

5F, Building H6, No.39 Ruihe Road, Guangzhou NaJin Science Park, Huangpu District, Guangzhou City,Guangdong province,510530 China
Tel:
020-38393880
Fax:
020-38390880
E-mail:
info@jd-biotech.com

Follow us

Wechat
粵ICP備18149706號 Copyright ?2004 - 2019 Guangzhou Jinde Biotech Co., Ltd.
丰满熟女人妻一区二区三 | 人人妻人人澡人人爽人人视频 | 真人黄色在线免费观看 | 精品人妻一区二区三区线国色天香 | 亚洲精品一区人人爽 | 海角社区综合久久中文字幕 | 9人妻偷拍 熟女网站 | 精品黑人一区二区三区久久 | 丰满少妇一级毛片视频 | 色情一区二区三区四区 | 国产在线拍揄自揄拍无码网站新闻 | 97人人添人人澡人人爽亚洲正品 | 波多野结衣精喷50连发 | 自慰喷白浆在线观看 | 成人A片产无码免费视频奶头鸭度 | 在线观看免费黄色小视频 | 川上优中文一区二区三区 | av免费在线观看免费在线观看 | 午夜在线免费视频 | 国产人妻无码一区二区三区不卡 | 少妇人妻色欲一区二区三区 | 欧美交换配乱婬粗大嫩模 | 91嫩草|国产丨精品入口 | 中文字幕黄色视频com | 国产成人在线电影网 | 亚洲AV无码秘 蜜桃蘑菇 | 欧美性精品一区二区三区久久久 | 国产精品偷乱一区二区三区 | 欧美成人网站在线观看 | 本日美女产国热妞久999 | 国产精品人妻无码久久久久 | 人人干人人干人人干 | 又粗又长又色在线播放 | 亚洲无码高清中文字幕 | 老外添女人囗交做爰视频 | 91精品少妇高潮一区二区三区不卡 | 四川少妇BBB搡BBB爽爽爽 | 特级做a爰片毛片免线看在线 | 精品一区二区三区呻吟声 | 一本大道伊人精品无码A色欲 | 国产精品99精品无码视亚 |